Cardigan Welsh Corgi Club of America

Advances in Lymphoma Research

An interesting announcement supporting the One Health approach (animals and humans) to looking at disease. Hopefully this might translate into screening for our dogs to see who might be at risk for developing lymphoma.


Scientists are rearranging the genetic information of certain dogs to make the coding human-like as a way to learn more about the genetic causes in people of non-Hodgkin’s lymphoma, a cancer that begins in the cells of the immune system. – (HealthDay, 4/12/2011). Reference Link Above 

Apparently there are some genes shared between human and canine lymphomas; the dog gene background is much less cluttered than the human one and is promising for future gene research. 

Also of interest (and great promise) in the same journal (Feb issue) is an article on a pilot study in dogs using a monoclonal antibody (mAb) therapy. The mAb binds to both normal and cancerous lymphocytes but only seems to induce suicide in cancerous cells. Very promising and early results indicate good safety. Now it appears to be headed to clinical trials. For those who have, have had or will have a dog with lymphoma, keep your fingers crossed as mAb therapy has been successful in some other cancers.